What is a common adverse effect of corticosteroids like methylprednisolone?

Corticosteroids such as methylprednisolone are known to have a range of effects on the body, with increased blood glucose levels being one of the most significant and common adverse effects. These medications are anti-inflammatory and immunosuppressive, and they can induce insulin resistance, which leads to elevated glucose levels in the blood. This is particularly important to monitor in patients with diabetes or those at risk for diabetes, as corticosteroids can exacerbate these conditions.

While corticosteroids can also influence other metabolic processes, such as fluid and electrolyte balance, the specific mechanism by which they raise blood glucose levels makes this effect noteworthy. Patients on corticosteroids often require careful monitoring of their blood sugar levels, especially if they are on the medication for an extended period.

The other options listed do not represent common adverse effects associated with corticosteroids. Low blood pressure and decreased heart rate are not typically associated with steroid use, as these medications usually have the opposite effect, potentially leading to hypertension and an increased heart rate. Weight loss is also not commonly seen with corticosteroid use; rather, they are often associated with weight gain due to increased appetite and fluid retention.