Which medications should a nurse be aware are contraindicated for use with warfarin?

The medications that are contraindicated for use with warfarin include Aspirin, Ginkgo biloba, and Ibuprofen primarily because these substances can increase the risk of bleeding. Warfarin is an anticoagulant that works by inhibiting vitamin K-dependent clotting factors, which makes it essential for nurses to be vigilant about any medications that could enhance its blood-thinning effects or disrupt its efficacy.

Aspirin is known to inhibit platelet function, further increasing the risk of hemorrhage when taken in conjunction with warfarin. Similarly, Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), can also irritate the gastrointestinal tract and when combined with warfarin can lead to gastrointestinal bleeding. Ginkgo biloba is an herbal supplement that can affect platelet aggregation and also pose a bleeding risk when used with anticoagulants.

In contrast, acetaminophen can typically be used with warfarin, though it should be monitored for potential hepatic effects with prolonged use. Medications like ciprofloxacin and amoxicillin do not have significant interactions with warfarin that would contraindicate their use. Prednisone and morphine also do not pose a direct risk when used with warfarin in most cases and are not typically contraindicated